Answer: Creatine XXL can stave off muscle loss during a break from resistance training, depending on your resistance training history, volume, and experience. The more exercise-induced muscle you have, the more you will lose when you stop resistance training. Interestingly, and to your point, creatine (contained in Creatine XXL) is often prescribed for sarcopenia (age-related muscle loss) in older adults to increase muscle strength and stave off the inevitable age decline in muscle.